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SPRR2A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P35326 |
| Other Accession | NP_005979.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 7965 Da |
| Antigen Region | 48-72 aa |
| Gene ID | 6700 |
|---|---|
| Other Names | Small proline-rich protein 2A, SPR-2A, 2-1, SPRR2A |
| Target/Specificity | This SPRR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-72 amino acids from the C-terminal region of human SPRR2A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SPRR2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPRR2A {ECO:0000303|PubMed:34735226, ECO:0000312|HGNC:HGNC:11261} |
|---|---|
| Function | Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635). |
| Cellular Location | Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. |
| Tissue Location | Expressed in intestine; selectively expressed in goblet cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
References
Kainu, K., et al. Exp. Dermatol. 18(2):109-115(2009)
Demetris, A.J., et al. J. Hepatol. 48(2):276-288(2008)
Tong, L., et al. Invest. Ophthalmol. Vis. Sci. 47(5):1938-1946(2006)
Hong, S.H., et al. Mol. Cells 17(3):477-484(2004)
Cabral, A., et al. J. Biol. Chem. 278(20):17792-17799(2003)
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