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OAZ2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O95190 |
| Other Accession | O08608, NP_002528.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21011 Da |
| Antigen Region | 125-151 aa |
| Gene ID | 4947 |
|---|---|
| Other Names | Ornithine decarboxylase antizyme 2, AZ2, ODC-Az 2, OAZ2 |
| Target/Specificity | This OAZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-151 amino acids from the C-terminal region of human OAZ2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OAZ2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OAZ2 |
|---|---|
| Function | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation. [provided by RefSeq].
References
Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Mangold, U., et al. Biochem. J. 385 (PT 1), 21-28 (2005) :
Chen, H., et al. J. Biol. Chem. 277(48):45957-45961(2002)
Coffino, P. Proc. Natl. Acad. Sci. U.S.A. 97(9):4421-4423(2000)
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