|Application ||WB, IHC-P, E|
|Other Accession||O08608, NP_002528.1|
|Calculated MW||21011 Da|
|Antigen Region||125-151 aa|
|Other Names||Ornithine decarboxylase antizyme 2, AZ2, ODC-Az 2, OAZ2|
|Target/Specificity||This OAZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-151 amino acids from the C-terminal region of human OAZ2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OAZ2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.|
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Provided below are standard protocols that you may find useful for product applications.
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation. [provided by RefSeq].
Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Mangold, U., et al. Biochem. J. 385 (PT 1), 21-28 (2005) :
Chen, H., et al. J. Biol. Chem. 277(48):45957-45961(2002)
Coffino, P. Proc. Natl. Acad. Sci. U.S.A. 97(9):4421-4423(2000)
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