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CWC22 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CWC22 Antibody  (N-term) AP10788a
    CWC22 Antibody (N-term) (Cat. #AP10788a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CWC22 antibody detected the CWC22 protein (arrow).
  • IHC-P - CWC22 Antibody  (N-term) AP10788a
    CWC22 antibody (N-term) (Cat. #AP10788a) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CWC22 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CWC22 Antibody  (N-term) AP10788a
    CWC22 Antibody (N-term) (Cat. #AP10788a) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HCG8
Other Accession NP_065994.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 105466 Da
Antigen Region 16-45 aa
Additional Information
Gene ID 57703
Other Names Pre-mRNA-splicing factor CWC22 homolog, Nucampholin homolog, fSAPb, CWC22, KIAA1604, NCM
Target/Specificity This CWC22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CWC22.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCWC22 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CWC22
Synonyms KIAA1604, NCM
Function Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Cellular Location Nucleus. Nucleus speckle. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins
Citations (0)

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May be involved in pre-mRNA splicing.


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Jurica, M.S., et al. RNA 8(4):426-439(2002)
Kelly, W.G., et al. Genetics 146(1):227-238(1997)

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Cat# AP10788a
(40 western blots)
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