|Application ||WB, E|
|Other Accession||Q99MK2, Q8CHK4|
|Calculated MW||58582 Da|
|Antigen Region||467-498 aa|
|Other Names||Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5, HTATIP, TIP60|
|Target/Specificity||This KAT5 / Tip60/HTATIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-498 amino acids from the C-terminal region of human KAT5 / Tip60/HTATIP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KAT5 / Tip60/HTATIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).|
|Cellular Location||Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies|
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Provided below are standard protocols that you may find useful for product applications.
HTATIP belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.
Cai, Y., et al., J. Biol. Chem. 280(14):13665-13670 (2005).
Patel, J.H., et al., Mol. Cell. Biol. 24(24):10826-10834 (2004).
Legube, G., et al., J. Biol. Chem. 279(43):44825-44833 (2004).
Franzese, O., et al., Cell Death Differ. 11(7):782-784 (2004).
Taubert, S., et al., Mol. Cell. Biol. 24(10):4546-4556 (2004).
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