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LARP6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q9BRS8 |
| Other Accession | NP_060827.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54737 Da |
| Antigen Region | 7-35 aa |
| Gene ID | 55323 |
|---|---|
| Other Names | La-related protein 6, Acheron, Achn, La ribonucleoprotein domain family member 6, LARP6 |
| Target/Specificity | This LARP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-35 amino acids from the N-terminal region of human LARP6. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LARP6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LARP6 |
|---|---|
| Function | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. |
| Cellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm |
| Tissue Location | Expressed in numerous tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LARP6 is a member of the La ribonucleoprotein domain family, which all contain one characteristic La motif. LARP6 shuttles between the cytoplasm and nucleus. It is proposed that members of this family play a role in translation and mRNA stability.
References
Cai, L., et al. J. Mol. Biol. 395(2):309-326(2010)
Glenn, H.L., et al. Am. J. Physiol., Cell Physiol. 298 (1), C46-C55 (2010) :
Valavanis, C., et al. Gene 393 (1-2), 101-109 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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