CEBPG Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P53567 |
Other Accession | P26801, P53568, Q3T0B9, NP_001797.1 |
Reactivity | Human, Mouse |
Predicted | Bovine, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 16408 Da |
Antigen Region | 83-110 aa |
Gene ID | 1054 |
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Other Names | CCAAT/enhancer-binding protein gamma, C/EBP gamma, CEBPG |
Target/Specificity | This CEBPG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-110 amino acids from the C-terminal region of human CEBPG. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CEBPG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CEBPG |
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Function | Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P53568}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Crawford, E.L., et al. Carcinogenesis 28(12):2552-2559(2007)
Mullins, D.N., et al. BMC Cancer 5, 141 (2005) :
Newman, J.R., et al. Science 300(5628):2097-2101(2003)
Hattori, T., et al. Oncogene 22(9):1273-1280(2003)
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