|Application ||WB, FC, E|
|Calculated MW||18045 Da|
|Antigen Region||16-45 aa|
|Other Names||Interleukin-17F, IL-17F, Cytokine ML-1, IL17F|
|Target/Specificity||This IL17F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human IL17F.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL17F Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).|
|Tissue Location||Expressed in activated, but not resting, CD4+ T-cells and activated monocytes|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Shu, Q., et al. Hum. Immunol. 71(10):988-991(2010)
Paradowska-Gorycka, A., et al. Scand. J. Immunol. 72(2):134-141(2010)
Tanasescu, C., et al. Eur. J. Intern. Med. 21(3):202-207(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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