|Application ||WB, FC, E|
|Calculated MW||131141 Da|
|Antigen Region||456-482 aa|
|Other Names||Alpha-mannosidase 2, Golgi alpha-mannosidase II, AMan II, Man II, Mannosidase alpha class 2A member 1, Mannosyl-oligosaccharide 1, 3-1, 6-alpha-mannosidase, MAN2A1, MANA2|
|Target/Specificity||This MAN2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-482 amino acids from the Central region of human MAN2A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAN2A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
Han, S., et al. Leuk. Res. 34(10):1271-1274(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhou, J.B., et al. Med. Sci. Monit. 16 (6), BR179-BR183 (2010) :
Miyagawa, H., et al. Rheumatology (Oxford) 47(2):158-164(2008)
Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :
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