|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||75379 Da|
|Antigen Region||605-634 aa|
|Other Names||Arginine--tRNA ligase, cytoplasmic, Arginyl-tRNA synthetase, ArgRS, RARS|
|Target/Specificity||This RARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 605-634 amino acids from the C-terminal region of human RARS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RARS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.|
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Provided below are standard protocols that you may find useful for product applications.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq].
Bottoni, A., et al. J. Cell. Physiol. 212(2):293-297(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Ling, C., et al. J. Biol. Chem. 280(41):34755-34763(2005)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Kaminska, M., et al. Biochemistry 40(47):14309-14316(2001)
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