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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FGD6 Antibody (C-term)   

FGD6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FGD6 Antibody (C-term) AP11108b
    FGD6 Antibody (C-term) (Cat. #AP11108b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FGD6 antibody detected the FGD6 protein (arrow).
  • IHC-P - FGD6 Antibody (C-term) AP11108b
    FGD6 Antibody (C-term) (Cat. #AP11108b)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FGD6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6ZV73
Other Accession NP_060821.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 160816 Da
Antigen Region 1324-1352 aa
Additional Information
Gene ID 55785
Other Names FYVE, RhoGEF and PH domain-containing protein 6, Zinc finger FYVE domain-containing protein 24, FGD6, KIAA1362, ZFYVE24
Target/Specificity This FGD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1324-1352 amino acids from the C-terminal region of human FGD6.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFGD6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGD6
Synonyms KIAA1362, ZFYVE24
Function May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton
Research Areas
Citations (0)

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Background

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

References

Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)

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Cat# AP11108b
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(40 western blots)
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