|Application ||WB, IHC-P, E|
|Calculated MW||160816 Da|
|Antigen Region||1324-1352 aa|
|Other Names||FYVE, RhoGEF and PH domain-containing protein 6, Zinc finger FYVE domain-containing protein 24, FGD6, KIAA1362, ZFYVE24|
|Target/Specificity||This FGD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1324-1352 amino acids from the C-terminal region of human FGD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGD6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.