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HIP1R Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | O75146 |
| Other Accession | NP_003950.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 119388 Da |
| Antigen Region | 98-126 aa |
| Gene ID | 9026 |
|---|---|
| Other Names | Huntingtin-interacting protein 1-related protein, HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R, HIP12, KIAA0655 |
| Target/Specificity | This HIP1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human HIP1R. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HIP1R Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HIP1R |
|---|---|
| Synonyms | HIP12, KIAA0655 |
| Function | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. |
| Cellular Location | Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region |
| Tissue Location | Brain, heart, kidney, pancreas, and liver, but not in lung or placenta |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kim, J.H., et al. Cell. Physiol. Biochem. 23 (1-3), 43-52 (2009) :
Wilbur, J.D., et al. J. Biol. Chem. 283(47):32870-32879(2008)
Poupon, V., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):168-173(2008)
Parker, J.A., et al. J. Neurosci. 27(41):11056-11064(2007)
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