|Application ||WB, IHC-P, FC, E|
|Calculated MW||119388 Da|
|Antigen Region||98-126 aa|
|Other Names||Huntingtin-interacting protein 1-related protein, HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R, HIP12, KIAA0655|
|Target/Specificity||This HIP1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human HIP1R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HIP1R Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.|
|Cellular Location||Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region|
|Tissue Location||Brain, heart, kidney, pancreas, and liver, but not in lung or placenta|
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Provided below are standard protocols that you may find useful for product applications.
This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kim, J.H., et al. Cell. Physiol. Biochem. 23 (1-3), 43-52 (2009) :
Wilbur, J.D., et al. J. Biol. Chem. 283(47):32870-32879(2008)
Poupon, V., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):168-173(2008)
Parker, J.A., et al. J. Neurosci. 27(41):11056-11064(2007)
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