|Application ||WB, E|
|Calculated MW||132024 Da|
|Antigen Region||966-995 aa|
|Other Names||Tudor domain-containing protein 1, Cancer/testis antigen 411, CT411, TDRD1|
|Target/Specificity||This TDRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 966-995 amino acids from the C-terminal region of human TDRD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TDRD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).|
|Cellular Location||Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis Also present in chromatoid body (By similarity).|
|Tissue Location||Testis and ovary specific. Also expressed in several cancers.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Wang, P.J., et al. Nat. Genet. 27(4):422-426(2001)
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