|Application ||WB, E|
|Other Accession||Q9ESN4, NP_001010908.1|
|Calculated MW||26719 Da|
|Antigen Region||22-50 aa|
|Other Names||Complement C1q-like protein 3, C1q and tumor necrosis factor-related protein 13, C1q/TNF-related protein 13, C1QL3, CTRP13|
|Target/Specificity||This C1QL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human C1QL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C1QL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).|
|Tissue Location||Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney|
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Provided below are standard protocols that you may find useful for product applications.
May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential).
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Koide, T., et al. J. Biol. Chem. 275(36):27957-27963(2000)
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