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TRMT2B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96GJ1 |
| Other Accession | NP_001161443.1, NP_079193.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56476 Da |
| Antigen Region | 136-165 aa |
| Gene ID | 79979 |
|---|---|
| Other Names | tRNA (uracil(54)-C(5))-methyltransferase homolog, TRM2 homolog, TRMT2B, CXorf34 |
| Target/Specificity | This TRMT2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the N-terminal region of human TRMT2B. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRMT2B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRMT2B {ECO:0000303|PubMed:31948311, ECO:0000312|HGNC:HGNC:25748} |
|---|---|
| Function | Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA (PubMed:31948311, PubMed:34556860). Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs (PubMed:31948311). Specifically methylates the uridine in position 429 of 12S rRNA (m5U429) (PubMed:31948311). Does not affect RNA stability or mitochondrial translation (PubMed:31948311). |
| Cellular Location | Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
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