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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CCNC Antibody (N-term)   

CCNC Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCNC Antibody (N-term) AP11208a
    CCNC Antibody (N-term) (Cat. #AP11208a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CCNC antibody detected the CCNC protein (arrow).
  • FC - CCNC Antibody (N-term) AP11208a
    CCNC Antibody (N-term) (Cat. #AP11208a) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24863
Other Accession NP_005181.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33243 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 892
Other Names Cyclin-C, SRB11 homolog, hSRB11, CCNC
Target/Specificity This CCNC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCNC.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Cellular Location Nucleus.
Tissue Location Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.


Miyata, Y., et al. Stem Cells 28(2):308-317(2010)
Makkonen, K.M., et al. J. Mol. Biol. 393(2):261-271(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Katona, R.L., et al. Acta. Biol. Hung. 58(1):133-137(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 295.00
$ 99.00
Cat# AP11208a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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