|Application ||WB, E|
|Other Accession||Q03229, NP_000105|
|Calculated MW||25454 Da|
|Antigen Region||168-197 aa|
|Other Names||Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3|
|Target/Specificity||This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EDN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endothelins are endothelium-derived vasoconstrictor peptides.|
|Tissue Location||Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Darrah, R., et al. Physiol. Genomics 41(1):71-77(2010)
Sanchez-Mejias, A., et al. Genet. Med. 12(1):39-43(2010)
Broasca, V., et al. Rom J Morphol Embryol 51(2):283-288(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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