|Application ||WB, IHC-P, FC, E|
|Calculated MW||35964 Da|
|Antigen Region||7-34 aa|
|Other Names||Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase, GGH|
|Target/Specificity||This GGH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human GGH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GGH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.|
|Cellular Location||Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq].
Adjei, A.A., et al. J Thorac Oncol 5(9):1346-1353(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Organista-Nava, J., et al. Leuk. Res. 34(6):728-732(2010)
Figueiredo, J.C., et al. Cancer Causes Control 21(4):597-608(2010)
Dervieux, T., et al. Pharmacogenet. Genomics (2009) In press :
If you have any additional inquiries please email technical services at email@example.com.