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ENG Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ENG Antibody (Center) AP11239C
    Western blot analysis of ENG (arrow) using rabbit polyclonal ENG Antibody (Center) (Cat. #AP11239c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ENG gene.
  • FC - ENG Antibody (Center) AP11239C
    ENG Antibody (Center) (Cat. #AP11239c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17813
Other Accession NP_001108225.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70578 Da
Antigen Region 265-294 aa
Additional Information
Gene ID 2022
Other Names Endoglin, CD105, ENG, END
Target/Specificity This ENG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the Central region of human ENG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsENG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENG
Synonyms END
Function Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Endoglin is restricted to endothelial cells in all tissues except bone marrow
Research Areas
Citations (0)

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This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


Lopez-Novoa, J.M., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (4), H959-H974 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zabaneh, D., et al. PLoS ONE 5 (8), E11961 (2010) :
Maynard, S.E., et al. Hypertens Pregnancy 29(3):330-341(2010)
Rius, C., et al. Blood 92(12):4677-4690(1998)

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$ 295.00
$ 99.00
Cat# AP11239C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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