|Application ||WB, E|
|Calculated MW||21422 Da|
|Antigen Region||129-156 aa|
|Other Names||Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone, CRH|
|Target/Specificity||This CRH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-156 amino acids from the C-terminal region of human CRH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.|
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Provided below are standard protocols that you may find useful for product applications.
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)
Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)
Kageyama, K., et al. Vitam. Horm. 82, 301-317 (2010) :
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