|Application ||WB, IHC-P, E|
|Calculated MW||58923 Da|
|Antigen Region||493-522 aa|
|Other Names||Keratin, type II cytoskeletal 73, Cytokeratin-73, CK-73, Keratin-73, K73, Type II inner root sheath-specific keratin-K6irs3, Type-II keratin Kb36, KRT73, K6IRS3, KB36, KRT6IRS3|
|Target/Specificity||This KRT73 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-522 amino acids from the C-terminal region of human KRT73.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KRT73 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||K6IRS3, KB36, KRT6IRS3|
|Function||Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).|
|Tissue Location||Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Langbein, L., et al. J. Invest. Dermatol. 120(4):512-522(2003)
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