|Application ||WB, IHC-P, IF, E|
|Calculated MW||44572 Da|
|Antigen Region||57-86 aa|
|Other Names||Phosphatidylinositol 4-phosphate 5-kinase-like protein 1, PI(4)P 5-kinase-like protein 1, PtdIns(4)P-5-kinase-like protein 1, PIP5KL1|
|Target/Specificity||This PIP5KL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-86 amino acids from the N-terminal region of human PIP5KL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIP5KL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.|
|Cellular Location||Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures.|
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Provided below are standard protocols that you may find useful for product applications.
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM].
Shi, L., et al. Mol. Biol. Rep. 37(5):2189-2198(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chang, J.D., et al. J. Biol. Chem. 279(12):11672-11679(2004)
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