|Application ||WB, E|
|Other Accession||NP_001480.3, NP_201591.2|
|Calculated MW||54383 Da|
|Antigen Region||30-59 aa|
|Other Names||Nuclear receptor subfamily 6 group A member 1, Germ cell nuclear factor, GCNF, hGCNF, Retinoid receptor-related testis-specific receptor, RTR, hRTR, NR6A1, GCNF|
|Target/Specificity||This NR6A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human NR6A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NR6A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).|
|Tissue Location||Shows highest expression in the germ cells of the adult testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants.
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Rajkovic, M., et al. J. Biol. Chem. 279(50):52493-52499(2004)
Yang, G., et al. Biol. Reprod. 68(5):1620-1630(2003)
Lan, Z.J., et al. J. Biol. Chem. 277(52):50660-50667(2002)
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