|Application ||WB, IHC-P, E|
|Other Accession||NP_055817.1, NP_296373.1|
|Calculated MW||72270 Da|
|Antigen Region||474-501 aa|
|Other Names||F-box only protein 21, FBXO21, FBX21, KIAA0875|
|Target/Specificity||This FBXO21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-501 amino acids from the C-terminal region of human FBXO21.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXO21 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)
Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)
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