|Application ||WB, E|
|Other Accession||Q4R7X8, Q5SYY0, NP_945356.1|
|Calculated MW||46941 Da|
|Antigen Region||326-354 aa|
|Other Names||Zinc finger protein 322, Zinc finger protein 322A, Zinc finger protein 388, Zinc finger protein 489, ZNF322, ZNF322A, ZNF388, ZNF489|
|Target/Specificity||This ZNF322B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human ZNF322B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF322B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ZNF322A, ZNF388, ZNF489|
|Function||Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly found in the nucleus.|
|Tissue Location||Ubiquitous. Highly expressed in heart and skeletal muscle.|
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May be involved in transcriptional regulation (By similarity).
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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