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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LRIT1 Antibody (C-term)   

LRIT1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LRIT1 Antibody (C-term) AP11414b
    LRIT1 Antibody (C-term) (Cat. #AP11414b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the LRIT1 antibody detected the LRIT1 protein (arrow).
  • FC - LRIT1 Antibody (C-term) AP11414b
    LRIT1 Antibody (C-term) (Cat. #AP11414b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q9P2V4
Other Accession NP_056428.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 594-622 aa
Additional Information
Other Names Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1, Leucine-rich repeat-containing protein 21, Photoreceptor-associated LRR superfamily protein, Retina-specific protein PAL, LRIT1, LRRC21, PAL
Target/Specificity This LRIT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-622 amino acids from the C-terminal region of human LRIT1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRIT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRIT1
Synonyms LRRC21, PAL
Function Possible role in phototransduction.
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JMH2}; Single-pass type I membrane protein EMBL; AB031547; BAA95681.1; -; mRNA EMBL; DQ426882; ABD90541.1; -; mRNA EMBL; AL080175; CAB45761.1; -; mRNA CCDS; CCDS7373.1; - PIR; T12497; T12497 RefSeq; NP_056428.1; NM_015613.2 UniGene; Hs.226000; - ProteinModelPortal; Q9P2V4; - SMR; Q9P2V4; - BioGrid; 117553; 1 STRING; 9606.ENSP00000361177; - iPTMnet; Q9P2V4; - PhosphoSitePlus; Q9P2V4; - BioMuta; LRIT1; - DMDM; 37081671; - PaxDb; Q9P2V4; - PeptideAtlas; Q9P2V4; - PRIDE; Q9P2V4; - ProteomicsDB; 83900; - DNASU; 26103; - Ensembl; ENST00000372105; ENSP00000361177; ENSG00000148602 GeneID; 26103; - KEGG; hsa:26103; - UCSC; uc001kcz.2; human CTD; 26103; - DisGeNET; 26103; - EuPathDB; HostDB:ENSG00000148602.5; - GeneCards; LRIT1; - HGNC; HGNC:23404; LRIT1 MIM; 616103; gene neXtProt; NX_Q9P2V4; - PharmGKB; PA162394331; - eggNOG; KOG0619; Eukaryota eggNOG; KOG3510; Eukaryota eggNOG; ENOG4110XFB; LUCA GeneTree; ENSGT00920000149011; - HOGENOM; HOG000063714; - HOVERGEN; HBG108105; - InParanoid; Q9P2V4; - OMA; WLPYNAL; - OrthoDB; EOG091G0BQ8; - PhylomeDB; Q9P2V4; - TreeFam; TF330861; - GenomeRNAi; 26103; - PRO; PR:Q9P2V4; - Proteomes; UP000005640; Chromosome 10 Bgee; ENSG00000148602; - CleanEx; HS_LRIT1; - Genevisible; Q9P2V4; HS GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB CDD; cd00063; FN3; 1 Gene3D; 2.60.40.10; -; 2 Gene3D; 3.80.10.10; -; 1 InterPro; IPR000483; Cys-rich_flank_reg_C InterPro; IPR003961; FN3_dom InterPro; IPR036116; FN3_sf InterPro; IPR007110; Ig-like_dom InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR013098; Ig_I-set InterPro; IPR003599; Ig_sub InterPro; IPR003598; Ig_sub2 InterPro; IPR001611; Leu-rich_rpt InterPro; IPR003591; Leu-rich_rpt_typical-subtyp InterPro; IPR032675; LRR_dom_sf Pfam; PF00041; fn3; 1 Pfam; PF07679; I-set; 1 Pfam; PF13855; LRR_8; 2 SMART; SM00409; IG; 1 SMART; SM00408; IGc2; 1 SMART; SM00369; LRR_TYP; 4 SMART; SM00082; LRRCT; 1 SUPFAM; SSF48726; SSF48726; 1 SUPFAM; SSF49265; SSF49265; 1 PROSITE; PS50853; FN3; 1 PROSITE; PS50835; IG_LIKE; 1 PROSITE; PS51450; LRR; 3 2: Evidence at transcript level; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 21 CHAIN 22 623 Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain- containing protein 1 /FTId=PRO_0000014835 TOPO_DOM 22 526 Lumenal. TRANSMEM 527 547 Helical. TOPO_DOM 548 623 Cytoplasmic. DOMAIN 22 59 LRRNT REPEAT 60 81 LRR 1 REPEAT 84 105 LRR 2 REPEAT 108 129 LRR 3 REPEAT 132 153 LRR 4 REPEAT 156 177 LRR 5 DOMAIN 201 253 LRRCT DOMAIN 266 335 Ig-like C2-type DOMAIN 430 518 Fibronectin type-III {ECO:0000255|PROSITE-ProRule:PRU00316} REPEAT 571 594 LRR 6. CARBOHYD 156 156 N-linked (GlcNAc...) asparagine CARBOHYD 296 296 N-linked (GlcNAc...) asparagine CARBOHYD 455 455 N-linked (GlcNAc...) asparagine DISULFID 275 328 {ECO:0000255|PROSITE-ProRule:PRU00114} VARIANT 154 154 L -> M (in dbSNP:rs11200933) /FTId=VAR_049891 VARIANT 258 258 P -> Q (in dbSNP:rs7090059) /FTId=VAR_049892 VARIANT 389 389 P -> T (in dbSNP:rs12262099) /FTId=VAR_049893 VARIANT 591 591 S -> G (in dbSNP:rs3814211) /FTId=VAR_020081 SEQUENCE 623 AA; 68041 MW; 1B5921E7DD4C0523 CRC64; MRVALGMLWL LALAWPPQAR GFCPSQCSCS LHIMGDGSKA RTVVCNDPDM TLPPASIPPD TSRLRLERTA IRRVPGEAFR PLGRLEQLWL PYNALSELNA LMLRGLRRLR ELRLPGNRLA AFPWAALRDA PKLRLLDLQA NRLSAVPAEA ARFLENLTFL DLSSNQLMRL PQELIVSWAH LETGIFPPGH HPRRVLGLQD NPWACDCRLY DLVHLLDGWA PNLAFIETEL RCASPRSLAG VAFSQLELRK CQGPELHPGV ASIRSLLGGT ALLRCGATGV PGPEMSWRRA NGRPLNGTVH QEVSSDGTSW TLLGLPAVSH LDSGDYICQA KNFLGASETV ISLIVTEPPT STEHSGSPGA LWARTGGGGE AAAYNNKLVA RHVPQIPKPA VLATGPSVPS TKEELTLEHF QMDALGELSD GRAGPSEARM VRSVKVVGDT YHSVSLVWKA PQAKNTTAFS VLYAVFGQHS MRRVIVQPGK TRVTITGLLP KTKYVACVCV QGLVPRKEQC VIFSTNEVVD AENTQQLINV VVISVAIVIA LPLTLLVCCS ALQKRCRKCF NKDSTEATVT YVNLERLGYS EDGLEELSRH SVSEADRLLS ARSSVDFQAF GVKGGRRINE YFC
Research Areas
Citations (0)

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Background

Possible role in phototransduction.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Gomi, F., et al. J. Neurosci. 20(9):3206-3213(2000)

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$ 295.00
$ 99.00
Cat# AP11414b
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(40 western blots)
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