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CRFR1 Antibody (Q103)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CRFR1 Antibody (Q103) AP11441a
    CRFR1 Antibody (Q103) (Cat. #AP11441a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR1 antibody detected the CRFR1 protein (arrow).
  • FC - CRFR1 Antibody (Q103) AP11441a
    CRFR1 Antibody (Q103) (Cat. #AP11441a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P34998
Other Accession P35353, NP_001138618.1, NP_004373.2
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50719 Da
Antigen Region 88-119 aa
Additional Information
Gene ID 104909134;1394
Other Names Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1, CRFR, CRFR1, CRHR
Target/Specificity This CRFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-119 amino acids from human CRFR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRFR1 Antibody (Q103) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRHR1
Synonyms CRFR, CRFR1, CRHR
Function G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis
Tissue Location Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe
Research Areas
Citations (0)

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This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants.


Karteris, E., et al. Endocrinology 151(10):4959-4968(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Hillhouse, E.W., et al. Endocr. Rev. 27(3):260-286(2006)

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$ 295.00
$ 99.00
Cat# AP11441a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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