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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KSR2 Antibody (C-term)   

KSR2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - KSR2 Antibody (C-term) AP11443b
    KSR2 Antibody (C-term) (Cat. #AP11443b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KSR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • WB - KSR2 Antibody (C-term) AP11443b
    KSR2 Antibody (C-term) (Cat. #AP11443b) western blot analysis in 293,K562,HepG2,Hela cell line lysates (35ug/lane).This demonstrates the KSR2 antibody detected the KSR2 protein (arrow).
  • FC - KSR2 Antibody (C-term) AP11443b
    KSR2 Antibody (C-term) (Cat. #AP11443b) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6VAB6
Other Accession NP_775869.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107632 Da
Antigen Region 603-638 aa
Additional Information
Gene ID 283455
Other Names Kinase suppressor of Ras 2, hKSR2, KSR2
Target/Specificity This KSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-638 amino acids from the C-terminal region of human KSR2.
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKSR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KSR2
Function Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Mainly expressed in brain and kidney.
Research Areas
Citations (0)

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Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.


Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liu, L., et al. Biochim. Biophys. Acta 1794(10):1485-1495(2009)
Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)

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$ 295.00
$ 99.00
Cat# AP11443b
(40 western blots)
Availability: In Stock
Bulk Size
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