|Application ||WB, IHC-P, E|
|Calculated MW||70109 Da|
|Antigen Region||281-307 aa|
|Other Names||Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain, F11|
|Target/Specificity||This F11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-307 amino acids from the Central region of human F11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||F11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.|
|Tissue Location||Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wong, P.C., et al. Thromb. Haemost. 104(2):302-310(2010)
Whelihan, M.F., et al. J. Thromb. Haemost. 8(7):1532-1539(2010)
Delluc, A., et al. Thromb. Haemost. 103(6):1161-1169(2010)
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :
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