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OBFC2B Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP11591b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP11591b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
OBFC2B Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9BQ15 |
| Other Accession | Q3SWT1, Q8R2Y9, A6QLK2, NP_076973.1 |
| Reactivity | Mouse |
| Predicted | Bovine, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 22338 Da |
OBFC2B Antibody (C-term) - Additional info | |
| Gene ID 79035 | |
| Other Names NABP2; OBFC2B; SSB1; SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1 | |
| Target/Specificity This OBFC2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-211 amino acids from the C-terminal region of human OBFC2B. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions OBFC2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
OBFC2B Antibody (C-term) - Protein Information | |
| Name NABP2 | |
| Synonyms OBFC2B, SSB1 | |
| Function Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways | |
| Cellular Location Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent Partial colocalization with RAD51 after ionizing radiation treatment | |
OBFC2B Antibody (C-term) - Related products
OBFC2B Antibody (C-term) - Application data
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OBFC2B Antibody (C-term) (Cat. #AP11591b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the OBFC2B antibody detected the OBFC2B protein (arrow).
OBFC2B Antibody (C-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM].
REFERENCES
Skaar, J.R., et al. J. Cell Biol. 187(1):25-32(2009) Li, Y., et al. J. Biol. Chem. 284(35):23525-23531(2009) Huang, J., et al. Mol. Cell 35(3):384-393(2009) Richard, D.J., et al. Nature 453(7195):677-681(2008) Lamesch, P., et al. Genomics 89(3):307-315(2007)
