|Application ||WB, E|
|Other Accession||Q3SWT1, Q8R2Y9, A6QLK2, NP_076973.1|
|Calculated MW||22338 Da|
|Antigen Region||183-211 aa|
|Other Names||SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, SOSS-B1, Single-stranded DNA-binding protein 1, hSSB1, NABP2, OBFC2B, SSB1|
|Target/Specificity||This OBFC2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human OBFC2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OBFC2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.|
|Cellular Location||Nucleus Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM].
Skaar, J.R., et al. J. Cell Biol. 187(1):25-32(2009)
Li, Y., et al. J. Biol. Chem. 284(35):23525-23531(2009)
Huang, J., et al. Mol. Cell 35(3):384-393(2009)
Richard, D.J., et al. Nature 453(7195):677-681(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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