|Application ||WB, IHC-P, E|
|Other Accession||Q8VHW5, Q8VHW2, NP_114101.4|
|Calculated MW||43313 Da|
|Antigen Region||90-119 aa|
|Other Names||Voltage-dependent calcium channel gamma-8 subunit, Neuronal voltage-gated calcium channel gamma-8 subunit, Transmembrane AMPAR regulatory protein gamma-8, TARP gamma-8, CACNG8, CACNG6|
|Target/Specificity||This CACNG8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human CACNG8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNG8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.
Sager, C., et al. Neuroscience 158(1):45-54(2009)
Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)
Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007)
Chu, P.J., et al. Gene 280 (1-2), 37-48 (2001) :
Burgess, D.L., et al. Genomics 71(3):339-350(2001)
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