|Application ||WB, IHC-P, E|
|Other Accession||Q5M9G1, Q8R409, Q0X0C4, NP_006451.1|
|Calculated MW||40623 Da|
|Antigen Region||194-222 aa|
|Other Names||Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1|
|Target/Specificity||This HEXIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human HEXIM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HEXIM1 antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLP1, EDG1, HIS1, MAQ1|
|Function||Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.|
|Cellular Location||Nucleus Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050)|
|Tissue Location||Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Dow, E.C., et al. J. Cell. Physiol. 224(1):84-93(2010)
Ogba, N., et al. Oncogene 29(25):3639-3649(2010)
Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)
Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)
Krueger, B.J., et al. PLoS ONE 5 (8), E12335 (2010) :
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