|Application ||WB, IHC-P, E|
|Other Accession||Q5M9G1, Q8R409, Q0X0C4, NP_006451.1|
|Calculated MW||40623 Da|
|Antigen Region||194-222 aa|
|Other Names||Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1|
|Target/Specificity||This HEXIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human HEXIM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HEXIM1 antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLP1, EDG1, HIS1, MAQ1|
|Function||Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.|
|Cellular Location||Nucleus Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050)|
|Tissue Location||Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Dow, E.C., et al. J. Cell. Physiol. 224(1):84-93(2010)
Ogba, N., et al. Oncogene 29(25):3639-3649(2010)
Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)
Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)
Krueger, B.J., et al. PLoS ONE 5 (8), E12335 (2010) :
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