Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC16A8 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95907 |
| Other Accession | NP_037488.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52319 Da |
| Antigen Region | 466-493 aa |
| Gene ID | 23539 |
|---|---|
| Other Names | Monocarboxylate transporter 3, MCT 3, Solute carrier family 16 member 8, SLC16A8, MCT3 |
| Target/Specificity | This SLC16A8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-493 amino acids from the C-terminal region of human SLC16A8. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC16A8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A8 (HGNC:16270) |
|---|---|
| Synonyms | MCT3 |
| Function | Probable retinal pigment epithelium (RPE)-specific proton- coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity). |
| Cellular Location | Basolateral cell membrane; Multi-pass membrane protein. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217) Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217} |
| Tissue Location | Retinal pigment epithelium. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM].
References
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Wilson, M.C., et al. J. Biol. Chem. 280(29):27213-27221(2005)
Halestrap, A.P., et al. Pflugers Arch. 447(5):619-628(2004)
Philp, N.J., et al. Invest. Ophthalmol. Vis. Sci. 44(4):1716-1721(2003)
Dunham, I., et al. Nature 402(6761):489-495(1999)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
