|Application ||WB, E|
|Calculated MW||52319 Da|
|Antigen Region||466-493 aa|
|Other Names||Monocarboxylate transporter 3, MCT 3, Solute carrier family 16 member 8, SLC16A8, MCT3|
|Target/Specificity||This SLC16A8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-493 amino acids from the C-terminal region of human SLC16A8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC16A8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Retinal pigment epithelium.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM].
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Wilson, M.C., et al. J. Biol. Chem. 280(29):27213-27221(2005)
Halestrap, A.P., et al. Pflugers Arch. 447(5):619-628(2004)
Philp, N.J., et al. Invest. Ophthalmol. Vis. Sci. 44(4):1716-1721(2003)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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