|Application ||IHC-P, WB, IF, E|
|Calculated MW||36923 Da|
|Antigen Region||157-186 aa|
|Other Names||Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L, EFNB2, EPLG5, HTKL, LERK5|
|Target/Specificity||This EFNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the Central region of human EFNB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EFNB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||EPLG5, HTKL, LERK5|
|Function||Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
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Bochenek, M.L., et al. J. Cell. Sci. 123 (PT 8), 1235-1246 (2010) :
Nakada, M., et al. Int. J. Cancer 126(5):1155-1165(2010)
Qin, H., et al. J. Biol. Chem. 285(1):644-654(2010)
Kwan Tat, S., et al. Arthritis Res. Ther. 11 (4), R119 (2009) :
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