CHRND Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
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Primary Accession | Q07001 |
Other Accession | NP_000742.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 58895 Da |
Antigen Region | 168-196 aa |
Gene ID | 1144 |
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Other Names | Acetylcholine receptor subunit delta, CHRND, ACHRD |
Target/Specificity | This CHRND antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the Central region of human CHRND. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CHRND Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CHRND (HGNC:1965) |
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Synonyms | ACHRD |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
References
Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Saccone, N.L., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (4), 453-466 (2009) :
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
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