|Application ||WB, IHC-P, E|
|Other Accession||P09023, NP_061825.2|
|Calculated MW||25432 Da|
|Antigen Region||128-155 aa|
|Other Names||Homeobox protein Hox-B6, Homeobox protein Hox-22, Homeobox protein Hox-2B, Homeobox protein Hu-2, HOXB6, HOX2B|
|Target/Specificity||This HOXB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 amino acids from the Central region of human HOXB6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOXB6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.
Ferrai, C., et al. Mol. Biol. Cell 20(15):3543-3551(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chen, T., et al. Eur. J. Hum. Genet. 15(1):23-28(2007)
Shen, W., et al. J. Biol. Chem. 279(38):39895-39904(2004)
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