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TP53INP1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TP53INP1 Antibody (N-term) AP11742a
    Western blot analysis of lysate from human skeletal muscle tissue lysate, using TP53INP1 Antibody (N-term)(Cat. #AP11742a). AP11742a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
  • WB - TP53INP1 Antibody (N-term) AP11742a
    TP53INP1 Antibody (N-term) (Cat. #AP11742a) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the TP53INP1 antibody detected the TP53INP1 protein (arrow).
  • IHC-P - TP53INP1 Antibody (N-term) AP11742a
    TP53INP1 Antibody (N-term) (Cat. #AP11742a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TP53INP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96A56
Other Accession NP_001129205.1, NP_150601.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27366 Da
Antigen Region 36-64 aa
Additional Information
Gene ID 94241
Other Names Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1, TP53INP1, P53DINP1, SIP
Target/Specificity This TP53INP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human TP53INP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTP53INP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53INP1
Synonyms P53DINP1, SIP
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Cellular Location Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.


Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)
Yeung, M.L., et al. Cancer Res. 68(21):8976-8985(2008)
Daniele, B. J. Clin. Gastroenterol. 42(4):336-337(2008)
Sawaya, M., et al. J. Clin. Gastroenterol. 42(4):351-355(2008)
Bernardo, M.V., et al. Biochem. Biophys. Res. Commun. 359(2):317-322(2007)

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$ 295.00
$ 99.00
Cat# AP11742a
(40 western blots)
Availability: In Stock
Bulk Size
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