|Application ||WB, IHC-P, FC, E|
|Calculated MW||84100 Da|
|Antigen Region||668-697 aa|
|Other Names||Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, CD168, HMMR, IHABP, RHAMM|
|Target/Specificity||This HMMR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 668-697 amino acids from the C-terminal region of human HMMR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HMMR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.|
|Cellular Location||Cell surface. Cytoplasm.|
|Tissue Location||Expressed in breast cancer cell lines and in normal breast tissue|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Huang, T.W., et al. Biomaterials 31(26):6701-6709(2010)
Nagel, S., et al. Exp. Hematol. 38(1):38-45(2010)
Gust, K.M., et al. Neoplasia 11(9):956-963(2009)
Shigeishi, H., et al. Int. J. Oncol. 34(6):1565-1571(2009)
Luczynski, W., et al. Neoplasma 56(5):428-434(2009)
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