|Application ||WB, FC, IHC-P, E|
|Other Accession||NP_065955.2, NP_001154826.1|
|Calculated MW||85401 Da|
|Antigen Region||21-50 aa|
|Other Names||Pleckstrin homology domain-containing family A member 4, PH domain-containing family A member 4, Phosphoinositol 3-phosphate-binding protein 1, PEPP-1, PLEKHA4, PEPP1|
|Target/Specificity||This PLEKHA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human PLEKHA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLEKHA4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Highly expressed in melanoma. Detected at low levels in heart, skeletal muscle, kidney, liver and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
PLEKHA4 binds specifically to phosphatidylinositol-3-phosphate (PtdIns3P), but not to other phosphoinositides.
Stelzl, U., et al. Cell 122(6):957-968(2005)
Dowler, S., et al. Biochem. J. 351 (PT 1), 19-31 (2000) :
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