|Application ||WB, IHC-P, E|
|Calculated MW||50327 Da|
|Antigen Region||4-31 aa|
|Other Names||Tubulin beta-1 chain, TUBB1|
|Target/Specificity||This TBB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of human TBB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton|
|Tissue Location||Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.
Anton, A.I., et al. Ann. Hematol. 89(11):1147-1154(2010)
Yin, S., et al. Mol. Cancer Ther. 9(2):327-335(2010)
Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)
Joe, P.A., et al. J. Biol. Chem. 284(7):4283-4291(2009)
Navarro-Nunez, L., et al. Thromb. Haemost. 100(6):1211-1213(2008)
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