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CSAD Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y600 |
| Other Accession | NP_057073.4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55023 Da |
| Antigen Region | 197-226 aa |
| Gene ID | 51380 |
|---|---|
| Other Names | Cysteine sulfinic acid decarboxylase, Cysteine-sulfinate decarboxylase, Sulfinoalanine decarboxylase, CSAD, CSD |
| Target/Specificity | This CSAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-226 amino acids from the Central region of human CSAD. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CSAD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CSAD |
|---|---|
| Synonyms | CSD |
| Function | Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. |
| Tissue Location | Expressed in liver and brain. Also expressed in both astrocytes and neurons, but lower levels are expressed in astrocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cysteine sulfinic acid decarboxylase (CSAD) catalyses the penultimate and rate limiting step of taurine synthesis. Taurine is an amino sulphonic acid and is one of the most abundant amino acids in the brain. It has been found to be essential to a number of biological processes such as development of the brain and eye, reproduction, diabetes, osmoregulation as well as the anti-inflammatory activity of leukocytes.
References
Park, E., et al. Biochim. Biophys. Acta 1574(3):403-406(2002)
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