|Application ||WB, IHC-P, E|
|Calculated MW||65999 Da|
|Antigen Region||131-160 aa|
|Other Names||Cyclic nucleotide-gated cation channel alpha-4, Cyclic nucleotide-gated channel alpha-4, CNG channel alpha-4, CNG-4, CNG4, CNGA4|
|Target/Specificity||This CNGA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human CNGA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNGA4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).
Hofmann, F., et al. Pharmacol. Rev. 57(4):455-462(2005)
Kelliher, K.R., et al. Proc. Natl. Acad. Sci. U.S.A. 100(7):4299-4304(2003)
Bradley, J., et al. Science 294(5549):2095-2096(2001)
Munger, S.D., et al. Science 294(5549):2172-2175(2001)
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