|Application ||WB, IHC-P, E|
|Calculated MW||65999 Da|
|Antigen Region||131-160 aa|
|Other Names||Cyclic nucleotide-gated cation channel alpha-4, Cyclic nucleotide-gated channel alpha-4, CNG channel alpha-4, CNG-4, CNG4, CNGA4|
|Target/Specificity||This CNGA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human CNGA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNGA4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).
Hofmann, F., et al. Pharmacol. Rev. 57(4):455-462(2005)
Kelliher, K.R., et al. Proc. Natl. Acad. Sci. U.S.A. 100(7):4299-4304(2003)
Bradley, J., et al. Science 294(5549):2095-2096(2001)
Munger, S.D., et al. Science 294(5549):2172-2175(2001)
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