|Application ||IHC-P, WB, FC, E|
|Calculated MW||32529 Da|
|Antigen Region||136-163 aa|
|Other Names||Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV, PRSS3, PRSS4, TRY3, TRY4|
|Target/Specificity||This PRSS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from the Central region of human PRSS3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRSS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PRSS4, TRY3, TRY4|
|Function||Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.|
|Tissue Location||Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.
Jiang, G., et al. Gut 59(11):1535-1544(2010)
Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010)
Salameh, M.A., et al. J. Biol. Chem. 285(3):1939-1949(2010)
Rosendahl, J., et al. Pancreatology 10 (2-3), 243-249 (2010) :
Koistinen, H., et al. Neuroscience 160(1):97-102(2009)
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