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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > OTOP1 Antibody (Center)
OTOP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q7RTM1 |
| Other Accession | Q7M734, Q80VM9, NP_819056.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67353 Da |
| Antigen Region | 360-388 aa |
| Gene ID | 133060 |
|---|---|
| Other Names | Otopetrin-1, OTOP1 |
| Target/Specificity | This OTOP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human OTOP1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTOP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTOP1 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19656} |
|---|---|
| Function | Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium {ECO:0000250|UniProtKB:Q80VM9} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
OTOP1 is required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity).
References
Hurle, B., et al. Hum. Mol. Genet. 12(7):777-789(2003)
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$ 365.00
$ 140.00
Cat# AP11995c
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