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OTOP1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - OTOP1 Antibody (Center) AP11995c
    OTOP1 Antibody (Center) (Cat. #AP11995c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the OTOP1 antibody detected the OTOP1 protein (arrow).
  • IHC-P - OTOP1 Antibody (Center) AP11995c
    OTOP1 Antibody (Center) (Cat. #AP11995c)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of OTOP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7RTM1
Other Accession Q7M734, Q80VM9, NP_819056.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67353 Da
Antigen Region 360-388 aa
Additional Information
Gene ID 133060
Other Names Otopetrin-1, OTOP1
Target/Specificity This OTOP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human OTOP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOTOP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OTOP1 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19656}
Function Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium. {ECO:0000250|UniProtKB:Q80VM9}
Research Areas
Citations (0)

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OTOP1 is required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity).


Hurle, B., et al. Hum. Mol. Genet. 12(7):777-789(2003)

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$ 295.00
$ 99.00
Cat# AP11995c
(40 western blots)
Availability: In Stock
Bulk Size
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