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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PCDHB15 Antibody (N-term)   

PCDHB15 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PCDHB15 Antibody (N-term) AP12017a
    PCDHB15 Antibody (N-term) (Cat. #AP12017a) western blot analysis in MDA-MB453,Jurkat,ZR-75-1,HL-60 cell line lysates (35ug/lane).This demonstrates the PCDHB15 antibody detected the PCDHB15 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y5E8
Other Accession NP_061758.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 113-140 aa
Additional Information
Other Names Protocadherin beta-15, PCDH-beta-15, PCDHB15
Target/Specificity This PCDHB15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-140 amino acids from the N-terminal region of human PCDHB15.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPCDHB15 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHB15
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein EMBL; AF152494; AAD43755.1; -; mRNA EMBL; AF217742; AAK51610.1; -; mRNA EMBL; BC038797; AAH38797.1; -; mRNA CCDS; CCDS4257.1; - RefSeq; NP_061758.1; NM_018935.3 UniGene; Hs.130757; - ProteinModelPortal; Q9Y5E8; - SMR; Q9Y5E8; - BioGrid; 121061; 25 IntAct; Q9Y5E8; 25 STRING; 9606.ENSP00000231173; - iPTMnet; Q9Y5E8; - PhosphoSitePlus; Q9Y5E8; - BioMuta; PCDHB15; - DMDM; 13431379; - EPD; Q9Y5E8; - PaxDb; Q9Y5E8; - PeptideAtlas; Q9Y5E8; - PRIDE; Q9Y5E8; - ProteomicsDB; 86347; - DNASU; 56121; - Ensembl; ENST00000231173; ENSP00000231173; ENSG00000113248 GeneID; 56121; - KEGG; hsa:56121; - UCSC; uc003lje.5; human CTD; 56121; - EuPathDB; HostDB:ENSG00000113248.5; - GeneCards; PCDHB15; - HGNC; HGNC:8686; PCDHB15 HPA; CAB026471; - HPA; HPA007172; - HPA; HPA074676; - MIM; 604967; gene MIM; 606341; gene neXtProt; NX_Q9Y5E8; - OpenTargets; ENSG00000113248; - PharmGKB; PA33031; - eggNOG; KOG3594; Eukaryota eggNOG; ENOG410XQHI; LUCA GeneTree; ENSGT00900000140770; - HOGENOM; HOG000220892; - HOVERGEN; HBG054878; - InParanoid; Q9Y5E8; - KO; K16494; - OMA; RVVSEDN; - OrthoDB; EOG091G024L; - PhylomeDB; Q9Y5E8; - TreeFam; TF332299; - GeneWiki; PCDHB15; - GenomeRNAi; 56121; - PRO; PR:Q9Y5E8; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000113248; - CleanEx; HS_PCDHB15; - ExpressionAtlas; Q9Y5E8; baseline and differential Genevisible; Q9Y5E8; HS GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0007155; P:cell adhesion; TAS:ProtInc GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro GO; GO:0007399; P:nervous system development; TAS:ProtInc GO; GO:0007416; P:synapse assembly; IBA:GO_Central InterPro; IPR002126; Cadherin InterPro; IPR015919; Cadherin-like InterPro; IPR032455; Cadherin_C InterPro; IPR020894; Cadherin_CS InterPro; IPR013164; Cadherin_N InterPro; IPR030733; PCDHB15 PANTHER; PTHR24028:SF97; PTHR24028:SF97; 1 Pfam; PF00028; Cadherin; 5 Pfam; PF08266; Cadherin_2; 1 Pfam; PF16492; Cadherin_C_2; 1 PRINTS; PR00205; CADHERIN SMART; SM00112; CA; 5 SUPFAM; SSF49313; SSF49313; 6 PROSITE; PS00232; CADHERIN_1; 5 PROSITE; PS50268; CADHERIN_2; 6 2: Evidence at transcript level; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 26 CHAIN 27 787 Protocadherin beta-15 /FTId=PRO_0000003942 TOPO_DOM 27 690 Extracellular. TRANSMEM 691 711 Helical. TOPO_DOM 712 787 Cytoplasmic. DOMAIN 35 133 Cadherin 1. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 138 242 Cadherin 2. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 247 347 Cadherin 3. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 352 451 Cadherin 4. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 456 561 Cadherin 5. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 568 671 Cadherin 6. {ECO:0000255|PROSITE- ProRule:PRU00043} CARBOHYD 418 418 N-linked (GlcNAc...) asparagine CARBOHYD 567 567 N-linked (GlcNAc...) asparagine VARIANT 474 474 S -> R (in dbSNP:rs618506) /FTId=VAR_019633 VARIANT 494 494 R -> Q (in dbSNP:rs618096) /FTId=VAR_019634 VARIANT 719 719 A -> V (in a breast cancer sample; somatic mutation) /FTId=VAR_036106 VARIANT 758 758 G -> V (in a breast cancer sample; somatic mutation) /FTId=VAR_036107 SEQUENCE 787 AA; 86329 MW; 8DE8D3A07B0B6A56 CRC64; MEPAGERFPE QRQVLILLLL LEVTLAGWEP RRYSVMEETE RGSFVANLAN DLGLGVGELA ERGARVVSED NEQGLQLDLQ TGQLILNEKL DREKLCGPTE PCIMHFQVLL KKPLEVFRAE LLVTDINDHS PEFPEREMTL KIPETSSLGT VFPLKKARDL DVGSNNVQNY NISPNSHFHV STRTRGDGRK YPELVLDTEL DREEQAELRL TLTAVDGGSP PRSGTVQILI LVLDANDNAP EFVQALYEVQ VPENSPVGSL VVKVSARDLD TGTNGEISYS LYYSSQEIDK PFELSSLSGE IRLIKKLDFE TMSSYDLDIE ASDGGGLSGK CSVSVKVLDV NDNFPELSIS SLTSPIPENS PETEVALFRI RDRDSGENGK MICSIQDDVP FKLKPSVENF YRLVTEGALD RETRAEYNIT ITITDLGTPR LKTEQSITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPRDPHLPL TSLVSINTDN GHLFALQSLD YEALQAFEFR VGATDRGFPA LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDVAKHRL VVLVKDNGEP PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVFLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSE SNDFKFLKPI FPNIVSQDSR RKSEFLE
Research Areas
Citations (0)

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Background

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

References

Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :
Wu, Q., et al. Genome Res. 11(3):389-404(2001)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)

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Cat# AP12017a
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