|Application ||WB, E|
|Other Accession||Q9DB42, NP_056955.2|
|Calculated MW||15199 Da|
|Antigen Region||62-88 aa|
|Other Names||Zinc finger protein 593, Zinc finger protein T86, ZNF593|
|Target/Specificity||This ZNF593 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-88 amino acids from the Central region of human ZNF593.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF593 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
ZNF593 negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
Hayes, P.L., et al. Protein Sci. 17(3):571-576(2008)
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
Terunuma, A., et al. Nucleic Acids Res. 25(10):1984-1990(1997)
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