- CITATIONS: 2
|Application ||WB, IHC-P, IF, E|
|Other Accession||P70124, NP_002630.2|
|Calculated MW||42100 Da|
|Antigen Region||94-123 aa|
|Other Names||Serpin B5, Maspin, Peptidase inhibitor 5, PI-5, SERPINB5, PI5|
|Target/Specificity||This Maspin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human Maspin.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Maspin Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Normal mammary epithelial cells.|
Provided below are standard protocols that you may find useful for product applications.
SERPINB5 is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Kim, J., et al. Tumour Biol. 31(5):471-476(2010)
Juengel, E., et al. World J Urol 28(4):465-471(2010)
Besgen, P., et al. J. Immunol. 184(9):5392-5402(2010)
Fung, C.L., et al. Histopathology 56(3):319-330(2010)
Adim, S.B., et al. World J Surg Oncol 8, 22 (2010) :
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