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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   JAG1 Antibody (C-term)   

JAG1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - JAG1 Antibody (C-term) AP12146b
    JAG1 Antibody (C-term) (Cat. #AP12146b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the JAG1 antibody detected the JAG1 protein (arrow).
  • FC - JAG1 Antibody (C-term) AP12146b
    JAG1 Antibody (C-term) (Cat. #AP12146b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78504
Other Accession Q63722, Q9QXX0, NP_000205.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 133799 Da
Antigen Region 1122-1150 aa
Additional Information
Gene ID 182
Other Names Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1
Target/Specificity This JAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1122-1150 amino acids from the C-terminal region of human JAG1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJAG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JAG1
Synonyms JAGL1
Function Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells
Research Areas
Citations (0)

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The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.


Foldi, J., et al. J. Immunol. 185(9):5023-5031(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kerns, D., et al. Schizophr. Res. 120 (1-3), 150-158 (2010) :
Siar, C.H., et al. Eur. J. Med. Res. 15(4):180-184(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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Cat# AP12146b
(40 western blots)
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