|Application ||WB, IHC-P, IF, E|
|Calculated MW||99369 Da|
|Antigen Region||204-232 aa|
|Other Names||Collagen alpha-1(XXI) chain, COL21A1, COL1AL|
|Target/Specificity||This COL21A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the N-terminal region of human COL21A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL21A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Cytoplasm. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle|
|Tissue Location||Highly expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus and placenta; moderately expressed in brain, colon, lung, prostate, spinal cord, salivary gland and vascular smooth-muscle cells and very weakly expressed in heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland and peripheral leukocytes Expression in heart was higher in the right ventricle and atrium than in the left ventricle and atrium|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the alpha chain of type XXI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XXI collagen is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. An alternatively spliced transcript variant has been described, but its full-length nature has yet to be determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Chou, M.Y., et al. Genomics 79(3):395-401(2002)
Tuckwell, D. Matrix Biol. 21(1):63-66(2002)
Fitzgerald, J., et al. FEBS Lett. 505(2):275-280(2001)
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