- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Other Accession||Q0VD19, NP_000534.3|
|Calculated MW||69752 Da|
|Antigen Region||391-419 aa|
|Other Names||Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1, ASM|
|Target/Specificity||This SMPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human SMPD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMPD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.|
|Cellular Location||Lysosome. Secreted|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Desnick, J.P., et al. Mol. Med. 16 (7-8), 316-321 (2010) : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
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