|Application ||WB, E|
|Other Accession||Q8IWL2, NP_001092138.1|
|Calculated MW||26182 Da|
|Antigen Region||174-202 aa|
|Other Names||Pulmonary surfactant-associated protein A2, PSP-A, PSPA, SP-A, SP-A2, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5, SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B|
|Target/Specificity||This SFTPA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-202 amino acids from the C-terminal region of human SFTPA2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFTPA2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B|
|Function||In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication.
Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) :
Maitra, M., et al. J. Biol. Chem. 285(29):22103-22113(2010)
Wang, G., et al. J. Biol. Chem. 285(16):11998-12010(2010)
El Saleeby, C.M., et al. J. Pediatr. 156(3):409-414(2010)
Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010)
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