SFTPA2B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8IWL1 |
Other Accession | Q8IWL2, NP_001092138.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26169 Da |
Antigen Region | 174-202 aa |
Gene ID | 729238 |
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Other Names | Pulmonary surfactant-associated protein A2, PSP-A, PSPA, SP-A, SP-A2, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5, SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B |
Target/Specificity | This SFTPA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-202 amino acids from the C-terminal region of human SFTPA2B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SFTPA2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SFTPA2 |
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Synonyms | COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B |
Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. |
Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication.
References
Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) :
Maitra, M., et al. J. Biol. Chem. 285(29):22103-22113(2010)
Wang, G., et al. J. Biol. Chem. 285(16):11998-12010(2010)
El Saleeby, C.M., et al. J. Pediatr. 156(3):409-414(2010)
Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010)
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